Cargando…

Prevalence and variation of CHIP in patients with aggressive lymphomas undergoing CD19-directed CAR T-cell treatment

Inflammation plays an important role in chimeric antigen receptor (CAR) T-cell therapy, especially in the pathophysiology of cytokine-release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS). Clonal hematopoiesis of indetermined potential (CHIP) has also been associa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teipel, Raphael, Kroschinsky, Frank, Kramer, Michael, Kretschmann, Theresa, Egger-Heidrich, Katharina, Krüger, Thomas, Ruhnke, Leo, Herold, Sylvia, Stasik, Sebastian, Sockel, Katja, Middeke, Jan M., Trautmann-Grill, Karolin, Bornhäuser, Martin, Thiede, Christian, von Bonin, Malte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Stimulus Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941459/ https://www.ncbi.nlm.nih.gov/pubmed/35008107 http://dx.doi.org/10.1182/bloodadvances.2021005747

Ejemplares similares

Long-Term Mixed Chimerism After Ex Vivo/In Vivo T Cell-Depleted Allogeneic Hematopoietic Cell Transplantation in Patients With Myeloid Neoplasms
por: Ruhnke, Leo, et al.
Publicado: (2021)

CAR T-cell therapy for secondary CNS DLBCL
por: Ahmed, Gulrayz, et al.
Publicado: (2021)

Aggressive B-cell lymphoma cases with 11q aberration patterns indicate a spectrum beyond Burkitt-like lymphoma
por: Gebauer, Niklas, et al.
Publicado: (2021)

CD19-directed CAR T-cell therapy for treatment of primary CNS lymphoma
por: Siddiqi, Tanya, et al.
Publicado: (2021)

Spatial heterogeneity and differential treatment response of acute myeloid leukemia and relapsed/refractory extramedullary disease after allogeneic hematopoietic cell transplantation
por: Kunadt, Desiree, et al.
Publicado: (2022)

Doxorubicin pharmacokinetics and toxicity in patients with aggressive lymphoma and hepatic impairment
por: Lai, Catherine, et al.
Publicado: (2022)

Neurofilament light chain serum levels correlate with the severity of neurotoxicity after CAR T-cell treatment
por: Schoeberl, Florian, et al.
Publicado: (2022)

Hematopoietic stem cell boost for persistent neutropenia after CAR T-cell therapy: a GLA/DRST study
por: Gagelmann, Nico, et al.
Publicado: (2022)

COVID-19 and CAR T cells: a report on current challenges and future directions from the EPICOVIDEHA survey by EHA-IDWP
por: Busca, Alessandro, et al.
Publicado: (2022)

Day 30 SUV(max) predicts progression in patients with lymphoma achieving PR/SD after CAR T-cell therapy
por: Al Zaki, Ajlan, et al.
Publicado: (2022)

Deciphering the genetic basis of immune thrombocytopenia: current evidence for genetic predisposition in adult ITP
por: Georgi, Julia-Annabell, et al.
Publicado: (2023)

Clonal hematopoiesis and its emerging effects on cellular therapies
por: von Bonin, Malte, et al.
Publicado: (2021)

Half-dose glucarpidase as efficient rescue for toxic methotrexate levels in patients with acute kidney injury
por: Heuschkel, Sandra, et al.
Publicado: (2021)

Prognostic value of low-level MRD in adult acute lymphoblastic leukemia detected by low- and high-throughput methods
por: Kotrová, Michaela, et al.
Publicado: (2022)

Klonale Hämatopoese – Bedeutung für die Zelltherapie
por: Teipel, Raphael, et al.
Publicado: (2022)

Allogeneic Stem Cell Transplantation with Sequential Melphalan-Based Conditioning in AML: Residual Morphological Blast Count Determines the Risk of Relapse
por: Sockel, Katja, et al.
Publicado: (2022)

Deep learning detects acute myeloid leukemia and predicts NPM1 mutation status from bone marrow smears
por: Eckardt, Jan-Niklas, et al.
Publicado: (2021)

Dissemination of extreme levels of extracellular vesicles: tissue factor activity in patients with severe COVID-19
por: Guervilly, Christophe, et al.
Publicado: (2021)

The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A
por: Wu, Shang-Chuen, et al.
Publicado: (2021)

Impact of sickle cell trait on morbidity and mortality from SARS-CoV-2 infection
por: Merz, Lauren E., et al.
Publicado: (2021)

IL-6 antagonists to replace systemic corticosteroids as the preferred anti-inflammatory therapy in patients with COVID-19?
por: Kow, Chia Siang, et al.
Publicado: (2022)

A novel class of ZNF384 aberrations in acute leukemia
por: Zaliova, Marketa, et al.
Publicado: (2021)

Anti-cysteine/spacer antibodies that open ADAMTS13 are a common feature in iTTP
por: De Waele, Laure, et al.
Publicado: (2021)

Rational biomarker development for the early and minimally invasive monitoring of AML
por: Abdelhamed, Sherif, et al.
Publicado: (2021)

TET2 mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes
por: Gurnari, Carmelo, et al.
Publicado: (2022)

JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1β
por: Yan, Yuhan, et al.
Publicado: (2022)

Worse outcome and distinct mutational pattern in follicular lymphoma with anti-HBc positivity
por: Fernández-Rodríguez, Concepción, et al.
Publicado: (2022)

Coevolving JAK2(V617F+)relapsed AML and donor T cells with PD-1 blockade after stem cell transplantation: an index case
por: Penter, Livius, et al.
Publicado: (2021)

Molecular diagnosis of T-cell lymphoma: a correlative study of PCR-based T-cell clonality assessment and targeted NGS
por: Syrykh, Charlotte, et al.
Publicado: (2021)

Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti–PD-1–based therapy
por: Abbas, Hussein A., et al.
Publicado: (2021)

Clinical care pathway for the evaluation of patients with suspected VITT after ChAdOx1 nCoV-19 vaccination
por: Lee, Agnes Y. Y., et al.
Publicado: (2022)

RNA sequencing of chronic GVHD skin lesions defines shared and unique inflammatory pathways characterizing lichen planus and morphea
por: Zouali, Habib, et al.
Publicado: (2022)

Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis
por: Laroche, Audree, et al.
Publicado: (2022)

The CLL comorbidity index in a population-based cohort: a tool for clinical care and research
por: Rotbain, Emelie C., et al.
Publicado: (2022)

Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern
por: Li, Maggie, et al.
Publicado: (2022)

Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors
por: Thompson, Ella R., et al.
Publicado: (2022)

CPX-351 induces remission in newly diagnosed pediatric secondary myeloid malignancies
por: Hu, Yixin, et al.
Publicado: (2022)

Toll-like receptor 4 selective inhibition in medullar microenvironment alters multiple myeloma cell growth
por: Lemaitre, Léa, et al.
Publicado: (2022)

Anti–IL-6 cytokine treatment has no impact on elevated hematocrit or splenomegaly in a polycythemia vera mouse model
por: Baldauf, Conny K., et al.
Publicado: (2022)

Genetic features and clinical outcomes of patients with isolated and comutated DDX41-mutated myeloid neoplasms
por: Alkhateeb, Hassan B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uge9m43390t11tko93g85jkees