BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes

The transcriptional repressor BCL11A is involved in hematological malignancies, B-cell development, and fetal-to-adult hemoglobin switching. However, the molecular mechanism by which it promotes the development of myeloid leukemia remains largely unknown. We find that Bcl11a cooperates with the pseu...

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Detalles Bibliográficos
Autores principales: Sunami, Yoshitaka, Yokoyama, Takashi, Yoshino, Seiko, Takahara, Tomoko, Yamazaki, Yukari, Harada, Hironori, Nakamura, Takuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941473/
https://www.ncbi.nlm.nih.gov/pubmed/34714913
http://dx.doi.org/10.1182/bloodadvances.2021004558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941473/
https://www.ncbi.nlm.nih.gov/pubmed/34714913
http://dx.doi.org/10.1182/bloodadvances.2021004558

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