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Checkpoint protein expression in the tumor microenvironment defines the outcome of classical Hodgkin lymphoma patients

Emerging evidence indicates a major impact for the tumor microenvironment (TME) and immune escape in the pathogenesis and clinical course of classical Hodgkin lymphoma (cHL). We used gene expression profiling (n = 88), CIBERSORT, and multiplex immunohistochemistry (n = 131) to characterize the immun...

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Detalles Bibliográficos
Autores principales: Karihtala, Kristiina, Leivonen, Suvi-Katri, Karjalainen-Lindsberg, Marja-Liisa, Chan, Fong Chun, Steidl, Christian, Pellinen, Teijo, Leppä, Sirpa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941476/
https://www.ncbi.nlm.nih.gov/pubmed/34941990
http://dx.doi.org/10.1182/bloodadvances.2021006189