Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system. DNA double-strand breaks (DSB) trigger VSG switching, and repair via gene conversio...

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Detalles Bibliográficos
Autores principales: McLaughlin, Emilia Jane, Rubio-Pena, Karinna, Dujeancourt-Henry, Annick, Glover, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941856/
https://www.ncbi.nlm.nih.gov/pubmed/35229632
http://dx.doi.org/10.1128/mbio.03847-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941856/
https://www.ncbi.nlm.nih.gov/pubmed/35229632
http://dx.doi.org/10.1128/mbio.03847-21

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