Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model

New treatment options against the widespread cancerogenic gastric pathogen Helicobacter pylori are urgently needed. We describe a novel screening procedure for inhibitors of H. pylori flagellar biosynthesis. The assay is based on a flaA flagellin gene-luciferase reporter fusion in H. pylori and was...

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Detalles Bibliográficos
Autores principales: Suerbaum, Sebastian, Coombs, Nina, Patel, Lubna, Pscheniza, Dimitri, Rox, Katharina, Falk, Christine, Gruber, Achim D., Kershaw, Olivia, Chhatwal, Patrick, Brönstrup, Mark, Bilitewski, Ursula, Josenhans, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941896/
https://www.ncbi.nlm.nih.gov/pubmed/35227071
http://dx.doi.org/10.1128/mbio.03755-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941896/
https://www.ncbi.nlm.nih.gov/pubmed/35227071
http://dx.doi.org/10.1128/mbio.03755-21

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