Cargando…

Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model

New treatment options against the widespread cancerogenic gastric pathogen Helicobacter pylori are urgently needed. We describe a novel screening procedure for inhibitors of H. pylori flagellar biosynthesis. The assay is based on a flaA flagellin gene-luciferase reporter fusion in H. pylori and was...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suerbaum, Sebastian, Coombs, Nina, Patel, Lubna, Pscheniza, Dimitri, Rox, Katharina, Falk, Christine, Gruber, Achim D., Kershaw, Olivia, Chhatwal, Patrick, Brönstrup, Mark, Bilitewski, Ursula, Josenhans, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941896/ https://www.ncbi.nlm.nih.gov/pubmed/35227071 http://dx.doi.org/10.1128/mbio.03755-21

Ejemplares similares

Correction for Suerbaum et al., “Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model”
por: Suerbaum, Sebastian, et al.
Publicado: (2022)

Dynamics of Lewis b Binding and Sequence Variation of the babA Adhesin Gene during Chronic Helicobacter pylori Infection in Humans
por: Nell, Sandra, et al.
Publicado: (2014)

Erratum for Nell et al., Dynamics of Lewis b Binding and Sequence Variation of the babA Adhesin Gene during Chronic Helicobacter pylori Infection in Humans
por: Nell, Sandra, et al.
Publicado: (2015)

Protein Activity Sensing in Bacteria in Regulating Metabolism and Motility
por: Alvarado, Alejandra, et al.
Publicado: (2020)

Flagellar Motility of Trypanosoma cruzi Epimastigotes
por: Ballesteros-Rodea, G., et al.
Publicado: (2012)

The core genome (m5)C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori
por: Estibariz, Iratxe, et al.
Publicado: (2019)

Intestinal Microbiota Composition of Interleukin-10 Deficient C57BL/6J Mice and Susceptibility to Helicobacter hepaticus-Induced Colitis
por: Yang, Ines, et al.
Publicado: (2013)

Helicobacter pylori colonization critically depends on postprandial gastric conditions
por: Bücker, Roland, et al.
Publicado: (2012)

Reversible inhibition of Chlamydomonas flagellar surface motility
Publicado: (1979)

Experimental dissection of flagellar surface motility in chlamydomonas
por: Hoffman, JL, et al.
Publicado: (1980)

Erratum to “Flagellar Motility of Trypanosoma cruzi Epimastigotes”
por: Ballesteros-Rodea, G., et al.
Publicado: (2012)

Intraflagellar transport drives flagellar surface motility
por: Shih, Sheng Min, et al.
Publicado: (2013)

Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50
por: Yang, Yong, et al.
Publicado: (2011)

EFFECTS OF TRYPSIN DIGESTION ON FLAGELLAR STRUCTURES AND THEIR RELATIONSHIP TO MOTILITY
por: Summers, Keith E., et al.
Publicado: (1973)

Modulation of Chlamydomonas reinhardtii flagellar motility by redox poise
por: Wakabayashi, Ken-ichi, et al.
Publicado: (2006)

Metformin Alters the Chemotaxis and Flagellar Motility of Escherichia coli
por: Ye, Yingxiang, et al.
Publicado: (2022)

Multiple functions of flagellar motility and chemotaxis in bacterial physiology
por: Colin, Remy, et al.
Publicado: (2021)

Clostridioides difficile minimal nutrient requirements for flagellar motility
por: Schwanbeck, Julian, et al.
Publicado: (2023)

A novel role of centrin in flagellar motility: stabilizing an inner-arm dynein motor in the flagellar axoneme
por: Li, Ziyin
Publicado: (2014)

A Global Overview of the Genetic and Functional Diversity in the Helicobacter pylori cag Pathogenicity Island
por: Olbermann, Patrick, et al.
Publicado: (2010)

Correction: A Global Overview of the Genetic and Functional Diversity in the Helicobacter pylori cag Pathogenicity Island
por: Olbermann, Patrick, et al.
Publicado: (2014)

Reactivation of flagellar motility in demembranated Leishmania reveals role of cAMP in flagellar wave reversal to ciliary waveform
por: Mukhopadhyay, Aakash Gautam, et al.
Publicado: (2016)

Giardia Flagellar Motility Is Not Directly Required to Maintain Attachment to Surfaces
por: House, Susan A., et al.
Publicado: (2011)

Reduced Protein Synthesis Fidelity Inhibits Flagellar Biosynthesis and Motility
por: Fan, Yongqiang, et al.
Publicado: (2016)

An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete
por: Gibson, Kimberley H, et al.
Publicado: (2020)

Role of the Two Flagellar Stators in Swimming Motility of Pseudomonas putida
por: Pfeifer, Veronika, et al.
Publicado: (2022)

Inhibition of Type IV Secretion Activity and Growth of Helicobacter pylori by Cisplatin and Other Platinum Complexes
por: Lettl, Clara, et al.
Publicado: (2020)

FlgV forms a flagellar motor ring that is required for optimal motility of Helicobacter pylori
por: Botting, Jack M., et al.
Publicado: (2023)

A motile Chlamydomonas flagellar mutant that lacks outer dynein arms
Publicado: (1985)

Flagellar Motility Is Critical for Salmonella enterica Serovar Typhimurium Biofilm Development
por: Wang, Feiying, et al.
Publicado: (2020)

Hypoosmotic stress induces flagellar biosynthesis and swimming motility in Escherichia albertii
por: Ikeda, Tetsuya, et al.
Publicado: (2020)

Agaric acid reduces Salmonella biofilm formation by inhibiting flagellar motility
por: Lories, Bram, et al.
Publicado: (2020)

Characterization of the Flagellar Collar Reveals Structural Plasticity Essential for Spirochete Motility
por: Chang, Yunjie, et al.
Publicado: (2021)

Flagellar polymorphism-dependent bacterial swimming motility in a structured environment
por: Kinosita, Yoshiaki, et al.
Publicado: (2023)

The Role of Soluble Adenylyl Cyclase in the Regulation of Flagellar Motility in Ascidian Sperm
por: Shiba, Kogiku, et al.
Publicado: (2023)

Helicobacter hepaticus Induces an Inflammatory Response in Primary Human Hepatocytes
por: Kleine, Moritz, et al.
Publicado: (2014)

Diversification of Campylobacter jejuni Flagellar C-Ring Composition Impacts Its Structure and Function in Motility, Flagellar Assembly, and Cellular Processes
por: Henderson, Louie D., et al.
Publicado: (2020)

In Vivo Genome and Methylome Adaptation of cag-Negative Helicobacter pylori during Experimental Human Infection
por: Estibariz, Iratxe, et al.
Publicado: (2020)

Characterizing the flagellar filament and the role of motility in bacterial prey-penetration by Bdellovibrio bacteriovorus
por: Lambert, Carey, et al.
Publicado: (2006)

Chlamydomonas reinhardtii hydin is a central pair protein required for flagellar motility
por: Lechtreck, Karl-Ferdinand, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_563kndto0gqkrrri0vs5ucvak9