Cargando…

Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience

BACKGROUND: Data on health status outcomes after spontaneous coronary artery dissection (SCAD) are limited. METHODS AND FINDINGS: Using the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) study we compared patients with SCAD and other acute myocardial infarction (AMI)...

Descripción completa

Detalles Bibliográficos
Autores principales: Murugiah, Karthik, Chen, Lian, Dreyer, Rachel P., Bouras, Georgios, Safdar, Basmah, Khera, Rohan, Lu, Yuan, Spatz, Erica S., Ng, Vivian G., Gupta, Aakriti, Bueno, Héctor, Tweet, Marysia S., Spertus, John A., Hayes, Sharonne N., Lansky, Alexandra, Krumholz, Harlan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942215/
https://www.ncbi.nlm.nih.gov/pubmed/35320296
http://dx.doi.org/10.1371/journal.pone.0265624
_version_ 1784673258612719616
author Murugiah, Karthik
Chen, Lian
Dreyer, Rachel P.
Bouras, Georgios
Safdar, Basmah
Khera, Rohan
Lu, Yuan
Spatz, Erica S.
Ng, Vivian G.
Gupta, Aakriti
Bueno, Héctor
Tweet, Marysia S.
Spertus, John A.
Hayes, Sharonne N.
Lansky, Alexandra
Krumholz, Harlan M.
author_facet Murugiah, Karthik
Chen, Lian
Dreyer, Rachel P.
Bouras, Georgios
Safdar, Basmah
Khera, Rohan
Lu, Yuan
Spatz, Erica S.
Ng, Vivian G.
Gupta, Aakriti
Bueno, Héctor
Tweet, Marysia S.
Spertus, John A.
Hayes, Sharonne N.
Lansky, Alexandra
Krumholz, Harlan M.
author_sort Murugiah, Karthik
collection PubMed
description BACKGROUND: Data on health status outcomes after spontaneous coronary artery dissection (SCAD) are limited. METHODS AND FINDINGS: Using the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) study we compared patients with SCAD and other acute myocardial infarction (AMI) at presentation (baseline), 1-month, and-12 months using standardized health status instruments. Among 3572 AMI patients ≤ 55 years, 67 had SCAD. SCAD patients were younger (median age (IQR) 45 (40.5–51) years vs. 48 (44–52) in other AMI, p = 0.003), more often female (92.5% vs. 66.6%), have college education (73.1% vs. 51.7%) and household income >$100,000 (43.3% vs. 17.7% (All p<0.001). SCAD patients at baseline had higher mean ± SD Short Form-12 [SF-12] physical component scores [PCS] (48.7±10.2 vs. 43.8±12.1, p<0.001) and mental component scores [MCS] (49.6±12.4 vs. 45.4±12.5, p = 0.008), and at 12-months [PCS (50.1±9.0 vs. 44.3±12.3, p<0.001) and MCS (53±10.1 vs 50.2±11.0, p = 0.045)]. The Euro-Quality of Life Scale [EQ-5D] VAS and EQ-5D index scores were similar at baseline, but higher at 12-months for SCAD (EQ-5D VAS: 82.2±10.2 vs. 72.3±21.0, p<0.001; EQ-5D index scores; 90.2±15.3 vs. 83.7±19.8, p = 0.012). SCAD patients had better baseline Seattle Angina Questionnaire [SAQ] physical limitation (88.8±20.1 vs. 81.2±25.4, p = 0.017). At 12-months SCAD patients had better physical limitation (98.0±8.5 vs. 91.4±18.8, p = 0.007), angina frequency (96.4±8.8 vs. 91.3±16.8, p = 0.018) and quality of life scores (80.7±14.7 vs 72.2±23.2, p = 0.005). Magnitude of change in health status from baseline to 12-months was not statistically different between the groups. After adjustment for time and comorbidities there remained no difference in most health status outcomes. CONCLUSIONS: SCAD patients fare marginally better than other AMI patients on most health status instruments and have similar 12-month health status recovery. Better pre-event health status suggests a need to modify exercise prescriptions and cardiac rehabilitation protocols to better assist this physically active population to recover.
format Online
Article
Text
id pubmed-8942215
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-89422152022-03-24 Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience Murugiah, Karthik Chen, Lian Dreyer, Rachel P. Bouras, Georgios Safdar, Basmah Khera, Rohan Lu, Yuan Spatz, Erica S. Ng, Vivian G. Gupta, Aakriti Bueno, Héctor Tweet, Marysia S. Spertus, John A. Hayes, Sharonne N. Lansky, Alexandra Krumholz, Harlan M. PLoS One Research Article BACKGROUND: Data on health status outcomes after spontaneous coronary artery dissection (SCAD) are limited. METHODS AND FINDINGS: Using the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) study we compared patients with SCAD and other acute myocardial infarction (AMI) at presentation (baseline), 1-month, and-12 months using standardized health status instruments. Among 3572 AMI patients ≤ 55 years, 67 had SCAD. SCAD patients were younger (median age (IQR) 45 (40.5–51) years vs. 48 (44–52) in other AMI, p = 0.003), more often female (92.5% vs. 66.6%), have college education (73.1% vs. 51.7%) and household income >$100,000 (43.3% vs. 17.7% (All p<0.001). SCAD patients at baseline had higher mean ± SD Short Form-12 [SF-12] physical component scores [PCS] (48.7±10.2 vs. 43.8±12.1, p<0.001) and mental component scores [MCS] (49.6±12.4 vs. 45.4±12.5, p = 0.008), and at 12-months [PCS (50.1±9.0 vs. 44.3±12.3, p<0.001) and MCS (53±10.1 vs 50.2±11.0, p = 0.045)]. The Euro-Quality of Life Scale [EQ-5D] VAS and EQ-5D index scores were similar at baseline, but higher at 12-months for SCAD (EQ-5D VAS: 82.2±10.2 vs. 72.3±21.0, p<0.001; EQ-5D index scores; 90.2±15.3 vs. 83.7±19.8, p = 0.012). SCAD patients had better baseline Seattle Angina Questionnaire [SAQ] physical limitation (88.8±20.1 vs. 81.2±25.4, p = 0.017). At 12-months SCAD patients had better physical limitation (98.0±8.5 vs. 91.4±18.8, p = 0.007), angina frequency (96.4±8.8 vs. 91.3±16.8, p = 0.018) and quality of life scores (80.7±14.7 vs 72.2±23.2, p = 0.005). Magnitude of change in health status from baseline to 12-months was not statistically different between the groups. After adjustment for time and comorbidities there remained no difference in most health status outcomes. CONCLUSIONS: SCAD patients fare marginally better than other AMI patients on most health status instruments and have similar 12-month health status recovery. Better pre-event health status suggests a need to modify exercise prescriptions and cardiac rehabilitation protocols to better assist this physically active population to recover. Public Library of Science 2022-03-23 /pmc/articles/PMC8942215/ /pubmed/35320296 http://dx.doi.org/10.1371/journal.pone.0265624 Text en © 2022 Murugiah et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Murugiah, Karthik
Chen, Lian
Dreyer, Rachel P.
Bouras, Georgios
Safdar, Basmah
Khera, Rohan
Lu, Yuan
Spatz, Erica S.
Ng, Vivian G.
Gupta, Aakriti
Bueno, Héctor
Tweet, Marysia S.
Spertus, John A.
Hayes, Sharonne N.
Lansky, Alexandra
Krumholz, Harlan M.
Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience
title Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience
title_full Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience
title_fullStr Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience
title_full_unstemmed Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience
title_short Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience
title_sort health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: the virgo experience
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942215/
https://www.ncbi.nlm.nih.gov/pubmed/35320296
http://dx.doi.org/10.1371/journal.pone.0265624
work_keys_str_mv AT murugiahkarthik healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT chenlian healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT dreyerrachelp healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT bourasgeorgios healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT safdarbasmah healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT kherarohan healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT luyuan healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT spatzericas healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT ngviviang healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT guptaaakriti healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT buenohector healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT tweetmarysias healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT spertusjohna healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT hayessharonnen healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT lanskyalexandra healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience
AT krumholzharlanm healthstatusoutcomesafterspontaneouscoronaryarterydissectionandcomparisonwithotheracutemyocardialinfarctionthevirgoexperience