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Evidence that nuclear receptors are related to terpene synthases

Ligand-activated nuclear receptors (NRs) orchestrate development, growth, and reproduction across all animal lifeforms – the Metazoa – but how NRs evolved remains mysterious. Given the NR ligands including steroids and retinoids are predominantly terpenoids, we asked whether NRs might have evolved f...

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Detalles Bibliográficos
Autores principales: Houston, Douglas R, Hanna, Jane G, Lathe, J Constance, Hillier, Stephen G, Lathe, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942334/
https://www.ncbi.nlm.nih.gov/pubmed/35112668
http://dx.doi.org/10.1530/JME-21-0156