Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain

Rhes (RASD2) is a thyroid hormone–induced gene that regulates striatal motor activity and promotes neurodegeneration in Huntington disease (HD) and tauopathy. Rhes moves and transports the HD protein, polyglutamine-expanded huntingtin (mHTT), via tunneling nanotube (TNT)–like membranous protrusions...

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Detalles Bibliográficos
Autores principales: Ramírez-Jarquín, Uri Nimrod, Sharma, Manish, Shahani, Neelam, Li, Yuqing, Boregowda, Siddaraju, Subramaniam, Srinivasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942366/
https://www.ncbi.nlm.nih.gov/pubmed/35319973
http://dx.doi.org/10.1126/sciadv.abm3877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942366/
https://www.ncbi.nlm.nih.gov/pubmed/35319973
http://dx.doi.org/10.1126/sciadv.abm3877

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