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Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain

Rhes (RASD2) is a thyroid hormone–induced gene that regulates striatal motor activity and promotes neurodegeneration in Huntington disease (HD) and tauopathy. Rhes moves and transports the HD protein, polyglutamine-expanded huntingtin (mHTT), via tunneling nanotube (TNT)–like membranous protrusions...

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Detalles Bibliográficos
Autores principales:	Ramírez-Jarquín, Uri Nimrod, Sharma, Manish, Shahani, Neelam, Li, Yuqing, Boregowda, Siddaraju, Subramaniam, Srinivasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942366/ https://www.ncbi.nlm.nih.gov/pubmed/35319973 http://dx.doi.org/10.1126/sciadv.abm3877

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