Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. The incr...

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Detalles Bibliográficos
Autores principales: Ramiro, Iris Bea L., Bjørn-Yoshimoto, Walden E., Imperial, Julita S., Gajewiak, Joanna, Salcedo, Paula Flórez, Watkins, Maren, Taylor, Dylan, Resager, William, Ueberheide, Beatrix, Bräuner-Osborne, Hans, Whitby, Frank G., Hill, Christopher P., Martin, Laurent F., Patwardhan, Amol, Concepcion, Gisela P., Olivera, Baldomero M., Safavi-Hemami, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942377/
https://www.ncbi.nlm.nih.gov/pubmed/35319982
http://dx.doi.org/10.1126/sciadv.abk1410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942377/
https://www.ncbi.nlm.nih.gov/pubmed/35319982
http://dx.doi.org/10.1126/sciadv.abk1410

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