Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models

The spike (S) protein of SARS-CoV-2 plays a crucial role in cell entry, and the nucleocapsid (N) protein is highly conserved among human coronavirus homologs. For potentially broad effectiveness against both original virus and emerging variants, we developed Alphavirus-based self-amplifying mRNA (sa...

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Detalles Bibliográficos
Autores principales: Palladino, Giuseppe, Chang, Cheng, Lee, Changkeun, Music, Nedzad, De Souza, Ivna, Nolasco, Jonathan, Amoah, Samuel, Suphaphiphat, Pirada, Otten, Gillis R., Settembre, Ethan C., Wen, Yingxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942436/
https://www.ncbi.nlm.nih.gov/pubmed/35345593
http://dx.doi.org/10.1016/j.omtm.2022.03.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942436/
https://www.ncbi.nlm.nih.gov/pubmed/35345593
http://dx.doi.org/10.1016/j.omtm.2022.03.013

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