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Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models
The spike (S) protein of SARS-CoV-2 plays a crucial role in cell entry, and the nucleocapsid (N) protein is highly conserved among human coronavirus homologs. For potentially broad effectiveness against both original virus and emerging variants, we developed Alphavirus-based self-amplifying mRNA (sa...
Autores principales: | Palladino, Giuseppe, Chang, Cheng, Lee, Changkeun, Music, Nedzad, De Souza, Ivna, Nolasco, Jonathan, Amoah, Samuel, Suphaphiphat, Pirada, Otten, Gillis R., Settembre, Ethan C., Wen, Yingxia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942436/ https://www.ncbi.nlm.nih.gov/pubmed/35345593 http://dx.doi.org/10.1016/j.omtm.2022.03.013 |
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