Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry

Coagulopathy is a significant aspect of morbidity in COVID-19 patients. The clotting cascade is propagated by a series of proteases, including factor Xa and thrombin. While certain host proteases, including TMPRSS2 and furin, are known to be important for cleavage activation of SARS-CoV-2 spike to p...

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Detalles Bibliográficos
Autores principales: Kastenhuber, Edward R, Mercadante, Marisa, Nilsson-Payant, Benjamin, Johnson, Jared L, Jaimes, Javier A, Muecksch, Frauke, Weisblum, Yiska, Bram, Yaron, Chandar, Vasuretha, Whittaker, Gary R, tenOever, Benjamin R, Schwartz, Robert E, Cantley, Lewis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942469/
https://www.ncbi.nlm.nih.gov/pubmed/35294338
http://dx.doi.org/10.7554/eLife.77444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942469/
https://www.ncbi.nlm.nih.gov/pubmed/35294338
http://dx.doi.org/10.7554/eLife.77444

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