The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII

Human (h) carbonic anhydrase (CAs, EC 4.2.1.1) isoforms IX and XII were recently confirmed as anticancer targets against solid hypoxic tumours. The “three-tails approach” has been proposed as an extension of the forerunner “tail” and “dual-tail approach” to fully exploit the amino acid differences a...

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Detalles Bibliográficos
Autores principales: Bonardi, Alessandro, Bua, Silvia, Combs, Jacob, Lomelino, Carrie, Andring, Jacob, Osman, Sameh Mohamed, Toti, Alessandra, Di Cesare Mannelli, Lorenzo, Gratteri, Paola, Ghelardini, Carla, McKenna, Robert, Nocentini, Alessio, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942523/
https://www.ncbi.nlm.nih.gov/pubmed/35306936
http://dx.doi.org/10.1080/14756366.2022.2053526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942523/
https://www.ncbi.nlm.nih.gov/pubmed/35306936
http://dx.doi.org/10.1080/14756366.2022.2053526

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