Activation mechanism of the class D fungal GPCR dimer Ste2

The fungal class D1 G-protein-coupled receptor (GPCR) Ste2 has a different arrangement of transmembrane helices compared with mammalian GPCRs and a distinct mode of coupling to the heterotrimeric G protein Gpa1–Ste2–Ste18(1). In addition, Ste2 lacks conserved sequence motifs such as DRY, PIF and NPX...

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Detalles Bibliográficos
Autores principales: Velazhahan, Vaithish, Ma, Ning, Vaidehi, Nagarajan, Tate, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942848/
https://www.ncbi.nlm.nih.gov/pubmed/35296853
http://dx.doi.org/10.1038/s41586-022-04498-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942848/
https://www.ncbi.nlm.nih.gov/pubmed/35296853
http://dx.doi.org/10.1038/s41586-022-04498-3

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