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Activation mechanism of the class D fungal GPCR dimer Ste2
The fungal class D1 G-protein-coupled receptor (GPCR) Ste2 has a different arrangement of transmembrane helices compared with mammalian GPCRs and a distinct mode of coupling to the heterotrimeric G protein Gpa1–Ste2–Ste18(1). In addition, Ste2 lacks conserved sequence motifs such as DRY, PIF and NPX...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942848/ https://www.ncbi.nlm.nih.gov/pubmed/35296853 http://dx.doi.org/10.1038/s41586-022-04498-3 |