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Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids
Mutations in N-glycanase 1 (NGLY1), which deglycosylates misfolded glycoproteins for degradation, can cause NGLY1 deficiency in patients and their abnormal fetal development in multiple organs, including microcephaly and other neurological disorders. Using cerebral organoids (COs) developed from hum...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942998/ https://www.ncbi.nlm.nih.gov/pubmed/35322011 http://dx.doi.org/10.1038/s41419-022-04693-0 |