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Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids

Mutations in N-glycanase 1 (NGLY1), which deglycosylates misfolded glycoproteins for degradation, can cause NGLY1 deficiency in patients and their abnormal fetal development in multiple organs, including microcephaly and other neurological disorders. Using cerebral organoids (COs) developed from hum...

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Detalles Bibliográficos
Autores principales:	Lin, Victor J. T., Hu, Jiangnan, Zolekar, Ashwini, Salick, Max R., Mittal, Parul, Bird, Jordan T., Hoffmann, Peter, Kaykas, Ajamete, Byrum, Stephanie D., Wang, Yu-Chieh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942998/ https://www.ncbi.nlm.nih.gov/pubmed/35322011 http://dx.doi.org/10.1038/s41419-022-04693-0

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