Down-regulation of the transcriptional repressor ZNF802 (JAZF1) reactivates fetal hemoglobin in β(0)-thalassemia/HbE

Reactivating of fetal hemoglobin (HbF; α2γ2) can ameliorate the severity of β-thalassemia disease by compensating for adult hemoglobin deficiency in patients. Previously, microarray analysis revealed that zinc finger protein (ZNF)802 (also known as Juxta-posed with another zinc finger gene-1 (JAZF1)...

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Detalles Bibliográficos
Autores principales: Wongborisuth, Chokdee, Chumchuen, Sukanya, Sripichai, Orapan, Anurathaphan, Usanarat, Sathirapongsasuti, Nuankanya, Songdej, Duantida, Tangprasittipap, Amornrat, Hongeng, Suradej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943019/
https://www.ncbi.nlm.nih.gov/pubmed/35322124
http://dx.doi.org/10.1038/s41598-022-08920-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943019/
https://www.ncbi.nlm.nih.gov/pubmed/35322124
http://dx.doi.org/10.1038/s41598-022-08920-8

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