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Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7

The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechanisms in various malignancies, leading to aberrant Rho GTPase signaling and thus facilitating cancer progression. Here we show that in breast cancer cells, dysregulation...

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Detalles Bibliográficos
Autores principales: Frey, Yannick, Franz-Wachtel, Mirita, Macek, Boris, Olayioye, Monilola A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943137/
https://www.ncbi.nlm.nih.gov/pubmed/35322810
http://dx.doi.org/10.1038/s41598-022-08844-3