PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation

Cyclic GMP-AMP synthase (cGAS) plays a major role in detecting pathogenic DNA. It produces cyclic dinucleotide cGAMP, which subsequently binds to the adaptor protein STING and further triggers antiviral innate immune responses. However, the molecular mechanisms regulating cGAS enzyme activity remain...

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Detalles Bibliográficos
Autores principales: Gu, Haiyan, Yang, Jing, Zhang, Jiayu, Song, Ying, Zhang, Yao, Xu, Pengfei, Zhu, Yuanxiang, Wang, Liangliang, Zhang, Pengfei, Li, Lin, Chen, Dahua, Sun, Qinmiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943206/
https://www.ncbi.nlm.nih.gov/pubmed/35322803
http://dx.doi.org/10.1038/s41467-022-29266-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943206/
https://www.ncbi.nlm.nih.gov/pubmed/35322803
http://dx.doi.org/10.1038/s41467-022-29266-9

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