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The paradox of Prader-Willi syndrome revisited: Making sense of the phenotype
Prader-Willi syndrome arises as a consequence of absent paternal copies of maternally imprinted genes at 15q11-13. Such gender-of-origin imprinted genes are expressed in the brain and also in mammalian placenta where paternally expressed imprinted genes drive foetal nutritional demand. We hypothesis...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943243/ https://www.ncbi.nlm.nih.gov/pubmed/35316681 http://dx.doi.org/10.1016/j.ebiom.2022.103952 |