The naturally occurring flavonoid nobiletin reverses methotrexate resistance via inhibition of P-glycoprotein synthesis

Methotrexate (MTX) is the first-line treatment for rheumatoid arthritis (RA). However, after long-term treatment, some patients develop resistance. P-glycoprotein (P-gp), as an indispensable drug transporter, is essential for mediating this MTX resistance. In addition, nobiletin (NOB), a naturally o...

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Detalles Bibliográficos
Autores principales: Liu, Rui, Song, Yurong, Li, Chenxi, Zhang, Zhengjia, Xue, Zeyu, Huang, Qingcai, Yu, Liuchunyang, Zhu, Dongjie, Cao, Zhiwen, Lu, Aiping, Lu, Cheng, Liu, Yuanyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943250/
https://www.ncbi.nlm.nih.gov/pubmed/35202652
http://dx.doi.org/10.1016/j.jbc.2022.101756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943250/
https://www.ncbi.nlm.nih.gov/pubmed/35202652
http://dx.doi.org/10.1016/j.jbc.2022.101756

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