The Pathogenic Sphingolipid Psychosine is Secreted in Extracellular Vesicles in the Brain of a Mouse Model of Krabbe Disease

Psychosine exerts most of its toxic effects by altering membrane dynamics with increased shedding of extracellular vesicles (EVs). In this study, we discovered that a fraction of psychosine produced in the brain of the Twitcher mouse, a model for Krabbe disease, is associated with secreted EVs. We e...

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Detalles Bibliográficos
Autores principales: Reiter, Cory R., Rebiai, Rima, Kwak, Angelika, Marshall, Jeff, Wozniak, Dylan, Scesa, Giusepe, Nguyen, Duc, Rue, Emily, Pathmasiri, Chandimal, Pijewski, Robert, van Breemen, Richard, Cologna, Stephanie, Crocker, Stephen J., Givogri, M Irene, Bongarzone, Ernesto R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943320/
https://www.ncbi.nlm.nih.gov/pubmed/35300522
http://dx.doi.org/10.1177/17590914221087817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943320/
https://www.ncbi.nlm.nih.gov/pubmed/35300522
http://dx.doi.org/10.1177/17590914221087817

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