Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci

Spreading depolarizations (SDs) indicate injury progression and predict worse clinical outcome in acute brain injury. We demonstrate in rodents that acute brain swelling upon cerebral ischemia impairs astroglial glutamate clearance and increases the tissue area invaded by SD. The cytotoxic extracell...

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Detalles Bibliográficos
Autores principales: Menyhárt, Ákos, Frank, Rita, Farkas, Attila E, Süle, Zoltán, Varga, Viktória É, Nyúl-Tóth, Ádám, Meiller, Anne, Ivánkovits-Kiss, Orsolya, Lemale, Coline L, Szabó, Írisz, Tóth, Réka, Zölei-Szénási, Dániel, Woitzik, Johannes, Marinesco, Stephane, Krizbai, István A, Bari, Ferenc, Dreier, Jens P, Farkas, Eszter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943616/
https://www.ncbi.nlm.nih.gov/pubmed/34427145
http://dx.doi.org/10.1177/0271678X211040056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943616/
https://www.ncbi.nlm.nih.gov/pubmed/34427145
http://dx.doi.org/10.1177/0271678X211040056

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