Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [(18)F]T-401 and PET

Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase that cleaves monoacylglycerols into fatty acids and is a potential target for the novel treatment of CNS disorders related to the endocannabinoid system and neuroinflammation. We have developed [(18)F]T-401 as a selective Positron emissi...

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Detalles Bibliográficos
Autores principales: Hattori, Yasushi, Seki, Chie, Maeda, Jun, Nagai, Yuji, Aoyama, Kazunobu, Zhang, Ming-Rong, Minamimoto, Takafumi, Koike, Tatsuki, Higuchi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943622/
https://www.ncbi.nlm.nih.gov/pubmed/34727758
http://dx.doi.org/10.1177/0271678X211058285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943622/
https://www.ncbi.nlm.nih.gov/pubmed/34727758
http://dx.doi.org/10.1177/0271678X211058285

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