Cargando…

Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [(18)F]T-401 and PET

Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase that cleaves monoacylglycerols into fatty acids and is a potential target for the novel treatment of CNS disorders related to the endocannabinoid system and neuroinflammation. We have developed [(18)F]T-401 as a selective Positron emissi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hattori, Yasushi, Seki, Chie, Maeda, Jun, Nagai, Yuji, Aoyama, Kazunobu, Zhang, Ming-Rong, Minamimoto, Takafumi, Koike, Tatsuki, Higuchi, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943622/ https://www.ncbi.nlm.nih.gov/pubmed/34727758 http://dx.doi.org/10.1177/0271678X211058285

Ejemplares similares

Synthesis and Preclinical Evaluation of Sulfonamido-based [(11)C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase
por: Wang, Lu, et al.
Publicado: (2016)

Monoacylglycerol Lipase Regulates Fever Response
por: Sanchez-Alavez, Manuel, et al.
Publicado: (2015)

Conformational Plasticity and Ligand Binding of Bacterial Monoacylglycerol Lipase
por: Rengachari, Srinivasan, et al.
Publicado: (2013)

Conformational gating, dynamics and allostery in human monoacylglycerol lipase
por: Tyukhtenko, Sergiy, et al.
Publicado: (2020)

Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer
por: Li, Xin, et al.
Publicado: (2019)

Localization of diacylglycerol lipase alpha and monoacylglycerol lipase during postnatal development of the rat retina
por: Cécyre, Bruno, et al.
Publicado: (2014)

N-terminal domain replacement changes an archaeal monoacylglycerol lipase into a triacylglycerol lipase
por: Soni, Surabhi, et al.
Publicado: (2019)

Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease
por: Tardelli, Matteo
Publicado: (2020)

Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases
por: Zanfirescu, Anca, et al.
Publicado: (2021)

Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration
por: Allaire, Manon, et al.
Publicado: (2023)

Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys
por: Eldridge, Mark A G, et al.
Publicado: (2015)

Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model
por: Oh-Nishi, Arata, et al.
Publicado: (2022)

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
por: Schlosburg, Joel E., et al.
Publicado: (2010)

Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
por: Costola-de-Souza, Carolina, et al.
Publicado: (2013)

Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase
por: Tyukhtenko, Sergiy, et al.
Publicado: (2018)

Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma
por: Zhang, Hao, et al.
Publicado: (2020)

A New Ultrasensitive Bioluminescence-Based Method for Assaying Monoacylglycerol Lipase
por: Miceli, Matteo, et al.
Publicado: (2021)

Endocannabinoid control of neuroinflammation in traumatic brain injury by monoacylglycerol lipase in astrocytes
por: Chen, Chu
Publicado: (2022)

Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum123
por: Chen, Yao, et al.
Publicado: (2016)

Monoacylglycerol Lipases Act as Evolutionarily Conserved Regulators of Non-oxidative Ethanol Metabolism
por: Heier, Christoph, et al.
Publicado: (2016)

Effect of Monoacylglycerol Lipase Inhibition on Intestinal Permeability of Rats With Severe Acute Pancreatitis
por: Wang, Jing, et al.
Publicado: (2022)

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
por: Bononi, Giulia, et al.
Publicado: (2022)

D(1)- and D(2)-like receptors differentially mediate the effects of dopaminergic transmission on cost–benefit evaluation and motivation in monkeys
por: Hori, Yukiko, et al.
Publicado: (2021)

Study on a Novel Cold-Active and Halotolerant Monoacylglycerol Lipase Widespread in Marine Bacteria Reveals a New Group of Bacterial Monoacylglycerol Lipases Containing Unusual C(A/S)HSMG Catalytic Motifs
por: Li, Ping-Yi, et al.
Publicado: (2020)

Modulation of mRNA Expression of Monoacylglycerol Lipase, Diacylglycerol Lipase and Cannabinoid Receptor-1 in Mice Experimentally Infected with T. gondii
por: Rostami-Mansoor, Sahar, et al.
Publicado: (2021)

Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants
por: Ogawa, Shintaro, et al.
Publicado: (2015)

Robust anti‐nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain
por: Burston, James J, et al.
Publicado: (2016)

Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma
por: Zhang, Junyong, et al.
Publicado: (2016)

Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
por: Xiang, Wei, et al.
Publicado: (2018)

The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition
por: Aschauer, Philipp, et al.
Publicado: (2018)

Monoacylglycerol Lipase Inhibition Protects From Liver Injury in Mouse Models of Sclerosing Cholangitis
por: Tardelli, Matteo, et al.
Publicado: (2019)

Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders
por: Deng, Hui, et al.
Publicado: (2020)

Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase
por: Afzal, Obaid, et al.
Publicado: (2021)

Corrigendum: Effect of Monoacylglycerol Lipase Inhibition on Intestinal Permeability of Rats With Severe Acute Pancreatitis
por: Wang, Jing, et al.
Publicado: (2022)

Monoacylglycerol lipase regulates macrophage polarization and cancer progression in uveal melanoma and pan-cancer
por: Tan, Yao, et al.
Publicado: (2023)

Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol
por: Kishimoto, Yasushi, et al.
Publicado: (2015)

3D-QSAR study of benzotriazol-1-yl carboxamide scaffold as monoacylglycerol lipase inhibitors
por: Afzal, Obaid, et al.
Publicado: (2014)

Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase
por: Liu, Xiaojie, et al.
Publicado: (2016)

Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss
por: Liu, Hui, et al.
Publicado: (2021)

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study
por: Jha, Vibhu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9v4t751q50t99bbabushhap0e7