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Mechanical force can enhance c-Src kinase activity by impairing autoinhibition

Cellular mechanosensing is pivotal for virtually all biological processes, and many molecular mechano-sensors and their way of function are being uncovered. In this work, we suggest that c-Src kinase acts as a direct mechano-sensor. c-Src is responsible for, among others, cell proliferation, and sho...

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Detalles Bibliográficos
Autores principales: Daday, Csaba, de Buhr, Svenja, Mercadante, Davide, Gräter, Frauke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943751/
https://www.ncbi.nlm.nih.gov/pubmed/35120901
http://dx.doi.org/10.1016/j.bpj.2022.01.028