Low pK(a) of Lys promotes glycation at one complementarity-determining region of a bispecific antibody

Protein glycation is a common, normally innocuous, post-translational modification in therapeutic monoclonal antibodies. However, when glycation occurs on complementarity-determining regions (CDRs) of a therapeutic monoclonal antibody, its biological activities (e.g., potency) may be impacted. Here,...

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Detalles Bibliográficos
Autores principales: Xu, Xiaobin, O'Callaghan, Jessica Ann, Guarnero, Zachary, Qiu, Haibo, Li, Ning, Potocky, Terra, Kamen, Douglas E., Graham, Kenneth S., Shameem, Mohammed, Yang, Teng-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943760/
https://www.ncbi.nlm.nih.gov/pubmed/35122736
http://dx.doi.org/10.1016/j.bpj.2022.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943760/
https://www.ncbi.nlm.nih.gov/pubmed/35122736
http://dx.doi.org/10.1016/j.bpj.2022.02.002

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