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Synaptotagmin-1 C2B domains cooperatively stabilize the fusion stalk via a master-servant mechanism
Synaptotagmin-1 is a low-affinity Ca(2+) sensor that triggers synchronous vesicle fusion. It contains two similar C2 domains (C2A and C2B) that cooperate in membrane binding, being the C2B domain mainly responsible for the membrane fusion process due to its polybasic patch KRLKKKKTTIKK (321–332). In...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943895/ https://www.ncbi.nlm.nih.gov/pubmed/35432859 http://dx.doi.org/10.1039/d1sc06711g |