Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias

Disrupting the methylation of telomeric silencing 1-like (DOT1L)-mediated histone H3 lysine 79 has been implicated in MLL fusion-mediated leukemogenesis. Recently, DOT1L has become an attractive therapeutic target for MLL-rearranged leukemias. Rigorous studies have been performed, and much progress...

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Detalles Bibliográficos
Autores principales: Yi, Yan, Ge, Shenglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944089/
https://www.ncbi.nlm.nih.gov/pubmed/35331314
http://dx.doi.org/10.1186/s13045-022-01251-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944089/
https://www.ncbi.nlm.nih.gov/pubmed/35331314
http://dx.doi.org/10.1186/s13045-022-01251-1

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