Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death

Nigratine (also known as 6E11), a flavanone derivative of a plant natural product, was characterized as highly specific non-ATP competitive inhibitor of RIPK1 kinase, one of the key components of necroptotic cell death signaling. We show here that nigratine inhibited both necroptosis (induced by Tum...

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Detalles Bibliográficos
Autores principales: Delehouzé, Claire, Comte, Arnaud, Leon-Icaza, Stephen Adonai, Cougoule, Céline, Hauteville, Marcelle, Goekjian, Peter, Bulinski, Jeannette Chloë, Dimanche-Boitrel, Marie-Thérèse, Meunier, Etienne, Rousselot, Morgane, Bach, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944179/
https://www.ncbi.nlm.nih.gov/pubmed/35332201
http://dx.doi.org/10.1038/s41598-022-09019-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944179/
https://www.ncbi.nlm.nih.gov/pubmed/35332201
http://dx.doi.org/10.1038/s41598-022-09019-w

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