Global genomic instability caused by reduced expression of DNA polymerase ε in yeast

DNA polymerase ε (Pol ε) is one of the three replicative eukaryotic DNA polymerases. Pol ε deficiency leads to genomic instability and multiple human diseases. Here, we explored global genomic alterations in yeast strains with reduced expression of POL2, the gene that encodes the catalytic subunit o...

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Detalles Bibliográficos
Autores principales: Zhang, Ke, Sui, Yang, Li, Wu-Long, Chen, Gen, Wu, Xue-Chang, Kokoska, Robert J., Petes, Thomas D., Zheng, Dao-Qiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944251/
https://www.ncbi.nlm.nih.gov/pubmed/35290114
http://dx.doi.org/10.1073/pnas.2119588119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944251/
https://www.ncbi.nlm.nih.gov/pubmed/35290114
http://dx.doi.org/10.1073/pnas.2119588119

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