Activation of the UPR sensor ATF6α is regulated by its redox-dependent dimerization and ER retention by ERp18

The unfolded protein response (UPR) maintains cellular proteostasis during stress by activating sensors located to the endoplasmic reticulum (ER) membrane. A major sensor for this response, ATF6α, is activated by release from ER retention and trafficking to the Golgi, where it is cleaved to generate...

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Detalles Bibliográficos
Autores principales: Oka, Ojore Benedict Valentine, Pierre, Arvin Shedrach, Pringle, Marie Anne, Tungkum, Wanida, Cao, Zhenbo, Fleming, Bethany, Bulleid, Neil John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944254/
https://www.ncbi.nlm.nih.gov/pubmed/35286189
http://dx.doi.org/10.1073/pnas.2122657119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944254/
https://www.ncbi.nlm.nih.gov/pubmed/35286189
http://dx.doi.org/10.1073/pnas.2122657119

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