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Activation of the UPR sensor ATF6α is regulated by its redox-dependent dimerization and ER retention by ERp18
The unfolded protein response (UPR) maintains cellular proteostasis during stress by activating sensors located to the endoplasmic reticulum (ER) membrane. A major sensor for this response, ATF6α, is activated by release from ER retention and trafficking to the Golgi, where it is cleaved to generate...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944254/ https://www.ncbi.nlm.nih.gov/pubmed/35286189 http://dx.doi.org/10.1073/pnas.2122657119 |