Cargando…

Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by memory and cognitive impairment, accompanied by the accumulation of extracellular deposits of amyloid β-peptide (Aβ) and the presence of neurofibrillary tangles (NFTs) composed of pathological forms of tau protein. Mitochondrial dysfunction and oxidative...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villavicencio-Tejo, Francisca, Olesen, Margrethe A., Aránguiz, Alejandra, Quintanilla, Rodrigo A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944569/ https://www.ncbi.nlm.nih.gov/pubmed/35326165 http://dx.doi.org/10.3390/antiox11030515

Ejemplares similares

Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease
por: Villavicencio Tejo, Francisca, et al.
Publicado: (2021)

The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders
por: Olesen, Margrethe A., et al.
Publicado: (2022)

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease
por: Pérez, María José, et al.
Publicado: (2018)

Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus
por: Jara, Claudia, et al.
Publicado: (2018)

Caspase Cleaved Tau in Alzheimer’s Disease: A Therapeutic Target Realized
por: Rohn, Troy T.
Publicado: (2015)

Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells
por: Quintanilla, Rodrigo A., et al.
Publicado: (2020)

A driver or a passenger? D421-caspase cleaved tau is associated with aggregated and insoluble tau
por: Gibson, Yolanda, et al.
Publicado: (2013)

Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits
por: Noël, Anastasia, et al.
Publicado: (2021)

Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways
por: Maldonado, Paloma P., et al.
Publicado: (2022)

Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain
por: Day, Ryan J., et al.
Publicado: (2015)

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease
por: Cheng, Ying, et al.
Publicado: (2018)

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer's Disease
por: Cabezas-Opazo, Fabian A., et al.
Publicado: (2015)

Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells
por: Licht, Verena, et al.
Publicado: (2014)

Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration
por: Pérez, María J., et al.
Publicado: (2018)

Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D
por: Jara, Claudia, et al.
Publicado: (2021)

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
por: Heilig, Rosalie, et al.
Publicado: (2020)

Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport
por: Conze, Christian, et al.
Publicado: (2022)

The Significance of Caspase-Cleaved Cytokeratin 18 in Pleural Effusion
por: Lee, Keu Sung, et al.
Publicado: (2014)

Caspase-3 cleaves hnRNP K in erythroid differentiation
por: Naarmann-de Vries, I S, et al.
Publicado: (2013)

Serum Caspase-Cleaved Cytokeratin (M30) Indicates Severity of Liver Dysfunction and Predicts Liver Outcome
por: Oweira, Hani, et al.
Publicado: (2018)

The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila
por: Fan, Yun, et al.
Publicado: (2009)

The Role of Mitochondrial Impairment in Alzheimer´s Disease Neurodegeneration: The Tau Connection
por: Quntanilla, Rodrigo A., et al.
Publicado: (2020)

Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis
por: Mancini, Marie, et al.
Publicado: (2000)

Nuclear localization of the caspase-3-cleaved form of p73 in anoikis
por: Alsafadi, Samar, et al.
Publicado: (2015)

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss
por: Olesen, Margrethe A., et al.
Publicado: (2020)

Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma
por: Liu, Pei-Feng, et al.
Publicado: (2017)

Cleaving the Acute Respiratory Distress Syndrome into Treatable Traits: A Role for Caspase 1?
por: Bos, Lieuwe D. J., et al.
Publicado: (2021)

High levels of cleaved caspase-3 in colorectal tumour stroma predict good survival
por: Noble, P, et al.
Publicado: (2013)

Total and caspase-cleaved cytokeratin 18 in chronic cholecystitis: A prospective study
por: Simopoulos, Constantinos, et al.
Publicado: (2008)

Active Caspases and Cleaved Cytokeratins Are Sequestered into Cytoplasmic Inclusions in Trail-Induced Apoptosis
por: MacFarlane, Marion, et al.
Publicado: (2000)

Chemotherapy increases caspase-cleaved cytokeratin 18 in the serum of breast cancer patients
por: Ulukaya, Engin, et al.
Publicado: (2011)

Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
por: Niu, Zhiyuan, et al.
Publicado: (2017)

Caspase-3 Cleaves Extracellular Vesicle Proteins During Auditory Brainstem Development
por: Weghorst, Forrest, et al.
Publicado: (2020)

Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer's Disease
por: Mondragón-Rodríguez, Siddhartha, et al.
Publicado: (2013)

Generation and characterization of antibodies specific for caspase-cleaved neo-epitopes: a novel approach
por: Ai, X, et al.
Publicado: (2011)

Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity
por: Opland, Carli K., et al.
Publicado: (2023)

Sam68 is cleaved by caspases under apoptotic cell death induced by ionizing radiation
por: Cho, Seong-Jun, et al.
Publicado: (2015)

Axonal Cleaved Caspase-3 Regulates Axon Targeting and Morphogenesis in the Developing Auditory Brainstem
por: Rotschafer, Sarah E., et al.
Publicado: (2016)

Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells
por: Yan, Liang, et al.
Publicado: (2021)

Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis
por: Ando, Kunie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7bjlkonbb7l1e1feocakt2f2jo