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Bending-torsional elasticity and energetics of the plus-end microtubule tip

Microtubules (MTs), mesoscopic cellular filaments, grow primarily by the addition of GTP-bound tubulin dimers at their dynamic flaring plus-end tips. They operate as chemomechanical energy transducers with stochastic transitions to an astounding shortening motion upon hydrolyzing GTP to GDP. Time-re...

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Detalles Bibliográficos
Autores principales: Igaev, Maxim, Grubmüller, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944587/
https://www.ncbi.nlm.nih.gov/pubmed/35302883
http://dx.doi.org/10.1073/pnas.2115516119