FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation

RNA modifications regulate a variety of cellular processes including DNA repair. The RNA methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) at DNA double-strand breaks (DSBs) in transcribed regions, promoting transcription-coupled homologous recombination (HR). Here,...

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Detalles Bibliográficos
Autores principales: Yang, Haibo, Wang, Yumin, Xiang, Yufei, Yadav, Tribhuwan, Ouyang, Jian, Phoon, Laiyee, Zhu, Xueping, Shi, Yi, Zou, Lee, Lan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944906/
https://www.ncbi.nlm.nih.gov/pubmed/35290126
http://dx.doi.org/10.1073/pnas.2116251119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944906/
https://www.ncbi.nlm.nih.gov/pubmed/35290126
http://dx.doi.org/10.1073/pnas.2116251119

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