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Single-molecule fluorescence imaging and deep learning reveal highly heterogeneous aggregation of amyloid-β 42
Polymorphism in the structure of amyloid fibrils suggests the existence of many different assembly pathways. Characterization of this heterogeneity is the key to understanding the aggregation mechanism and toxicity, but in practice it is extremely difficult to probe individual aggregation pathways i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944908/ https://www.ncbi.nlm.nih.gov/pubmed/35290118 http://dx.doi.org/10.1073/pnas.2116736119 |