Interleukin-2 superkines by computational design

Affinity maturation of protein–protein interactions is an important approach in the development of therapeutic proteins such as cytokines. Typical experimental strategies involve targeting the cytokine-receptor interface with combinatorial libraries and then selecting for higher-affinity variants. M...

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Detalles Bibliográficos
Autores principales: Ren, Junming, Chu, Alexander E., Jude, Kevin M., Picton, Lora K., Kare, Aris J., Su, Leon, Montano Romero, Alejandra, Huang, Po-Ssu, Garcia, K. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944926/
https://www.ncbi.nlm.nih.gov/pubmed/35294290
http://dx.doi.org/10.1073/pnas.2117401119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944926/
https://www.ncbi.nlm.nih.gov/pubmed/35294290
http://dx.doi.org/10.1073/pnas.2117401119

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