An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice

Acute traumatic coagulopathy (ATC) occurs in approximately 30% of patients with trauma and is associated with increased mortality. Excessive generation of activated protein C (APC) and hyperfibrinolysis are believed to be driving forces for ATC. Two mouse models were used to investigate whether an e...

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Detalles Bibliográficos
Autores principales: Joseph, Bilgimol Chumappumkal, Miyazawa, Byron Y., Esmon, Charles T., Cohen, Mitchell J., von Drygalski, Annette, Mosnier, Laurent O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945312/
https://www.ncbi.nlm.nih.gov/pubmed/34861695
http://dx.doi.org/10.1182/bloodadvances.2021005257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945312/
https://www.ncbi.nlm.nih.gov/pubmed/34861695
http://dx.doi.org/10.1182/bloodadvances.2021005257

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