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An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice
Acute traumatic coagulopathy (ATC) occurs in approximately 30% of patients with trauma and is associated with increased mortality. Excessive generation of activated protein C (APC) and hyperfibrinolysis are believed to be driving forces for ATC. Two mouse models were used to investigate whether an e...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Hematology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945312/ https://www.ncbi.nlm.nih.gov/pubmed/34861695 http://dx.doi.org/10.1182/bloodadvances.2021005257 |