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Vemurafenib acts as a molecular on-off switch governing systemic inflammation in Langerhans cell histiocytosis
Langerhans cell histiocytosis (LCH) is a neoplasm marked by the accumulation of CD1A(+)CD207(+) cells. It is most commonly driven by a somatic, activating mutation in the BRAF serine-threonine kinase (BRAF(V600E)). Multisystem disease with risk-organ involvement requires myelotoxic chemotherapy, mak...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Hematology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945316/ https://www.ncbi.nlm.nih.gov/pubmed/34619771 http://dx.doi.org/10.1182/bloodadvances.2021005442 |