Platelet binding to polymerizing fibrin is avidity driven and requires activated αIIbβ3 but not fibrin cross-linking

The molecular basis of platelet-fibrin interactions remains poorly understood despite the predominance of fibrin in thrombi. We have studied the interaction of platelets with polymerizing fibrin by adding thrombin to washed platelets in the presence of the peptide RGDW, which inhibits the initial pl...

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Detalles Bibliográficos
Autores principales: Buitrago, Lorena, Lefkowitz, Samuel, Bentur, Ohad, Padovan, Julio, Coller, Barry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945615/
https://www.ncbi.nlm.nih.gov/pubmed/34647980
http://dx.doi.org/10.1182/bloodadvances.2021005142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945615/
https://www.ncbi.nlm.nih.gov/pubmed/34647980
http://dx.doi.org/10.1182/bloodadvances.2021005142

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