A novel mechanism of thrombocytopenia by PS exposure through TMEM16F in sphingomyelin synthase 1 deficiency

Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. Here, we describe the hematologic phenotypes, such as reduced circulating platelets and dysfunctional hemostasis, in SMS1-deficient (SMS1-KO) mice. SMS1-KO mi...

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Detalles Bibliográficos
Autores principales: Fujii, Yoritaka, Taniguchi, Makoto, Nagaya, Shingo, Ueda, Yoshibumi, Hashizume, Chieko, Watanabe, Ken, Takeya, Hiroyuki, Kosaka, Takeo, Okazaki, Toshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945624/
https://www.ncbi.nlm.nih.gov/pubmed/34478523
http://dx.doi.org/10.1182/bloodadvances.2020002922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945624/
https://www.ncbi.nlm.nih.gov/pubmed/34478523
http://dx.doi.org/10.1182/bloodadvances.2020002922

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