Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma

Antiapoptotic Bcl-2 family members have recently (re)emerged as key drug targets in cancer, with a tissue- and tumor-specific activity profile of available BH3 mimetics. In multiple myeloma, MCL-1 has been described as a major gatekeeper of apoptosis. This discovery has led to the rapid establishmen...

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Detalles Bibliográficos
Autores principales: Bolomsky, Arnold, Miettinen, Juho J., Malyutina, Alina, Besse, Andrej, Huber, Julia, Fellinger, Stefanie, Breid, Helene, Parsons, Alun, Klavins, Kristaps, Hannich, J. Thomas, Kubicek, Stefan, Caers, Jo, Hübl, Wolfgang, Schreder, Martin, Zojer, Niklas, Driessen, Christoph, Tang, Jing, Besse, Lenka, Heckman, Caroline A., Ludwig, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945627/
https://www.ncbi.nlm.nih.gov/pubmed/34478517
http://dx.doi.org/10.1182/bloodadvances.2020003826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945627/
https://www.ncbi.nlm.nih.gov/pubmed/34478517
http://dx.doi.org/10.1182/bloodadvances.2020003826

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