TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signaling

Myelodysplastic syndrome (MDS) is a hematological malignancy characterized by blood cytopenias and predisposition to acute myeloid leukemia (AML). Therapies for MDS are lacking, particularly those that have an impact in the early stages of disease. We developed a model of MDS in zebrafish with knock...

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Detalles Bibliográficos
Autores principales: Peña, Oscar A., Lubin, Alexandra, Hockings, Catherine, Rowell, Jasmine, Jung, Youngrock, Hoade, Yvette, Dace, Phoebe, Valdivia, Leonardo E., Tuschl, Karin, Böiers, Charlotta, Virgilio, Maria C., Richardson, Simon, Payne, Elspeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945628/
https://www.ncbi.nlm.nih.gov/pubmed/34432872
http://dx.doi.org/10.1182/bloodadvances.2020003055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945628/
https://www.ncbi.nlm.nih.gov/pubmed/34432872
http://dx.doi.org/10.1182/bloodadvances.2020003055

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