Cargando…

The Pyrazolo[3,4-d]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma

Si306, a pyrazolo[3,4-d]pyrimidine derivative recently identified as promising anticancer agent, has shown favorable in vitro and in vivo activity profile against neuroblastoma (NB) models by acting as a competitive inhibitor of c-Src tyrosine kinase. Nevertheless, Si306 antitumor activity is associ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rango, Enrico, Pastorino, Fabio, Brignole, Chiara, Mancini, Arianna, Poggialini, Federica, Di Maria, Salvatore, Zamperini, Claudio, Iovenitti, Giulia, Fallacara, Anna Lucia, Sabetta, Samantha, Clementi, Letizia, Valoti, Massimo, Schenone, Silvia, Angelucci, Adriano, Ponzoni, Mirco, Dreassi, Elena, Botta, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945814/ https://www.ncbi.nlm.nih.gov/pubmed/35327462 http://dx.doi.org/10.3390/biomedicines10030659

Ejemplares similares

A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor
por: Fallacara, Anna Lucia, et al.
Publicado: (2019)

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery
por: Vignaroli, Giulia, et al.
Publicado: (2016)

Src Inhibitors Pyrazolo[3,4-d]pyrimidines, Si306 and Pro-Si306, Inhibit Focal Adhesion Kinase and Suppress Human Glioblastoma Invasion In Vitro and In Vivo
por: Nešović, Marija, et al.
Publicado: (2020)

Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme
por: Poggialini, Federica, et al.
Publicado: (2023)

Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors
por: Greco, Chiara, et al.
Publicado: (2020)

Autophagy Inhibition Enhances Anti-Glioblastoma Effects of Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors
por: Jovanović Stojanov, Sofija, et al.
Publicado: (2022)

Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor
por: Contadini, Claudia, et al.
Publicado: (2023)

Targeting Macrophages as a Potential Therapeutic Intervention: Impact on Inflammatory Diseases and Cancer
por: Ponzoni, Mirco, et al.
Publicado: (2018)

Sweet Cherry Extract as Permeation Enhancer of Tyrosine Kinase Inhibitors: A Promising Prospective for Future Oral Anticancer Therapies
por: Poggialini, Federica, et al.
Publicado: (2023)

Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors Induce Oxidative Stress in Patient-Derived Glioblastoma Cells
por: Kostić, Ana, et al.
Publicado: (2021)

New Therapeutic Strategy for Overcoming Multidrug Resistance in Cancer Cells with Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors
por: Podolski-Renić, Ana, et al.
Publicado: (2021)

A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies
por: Laurenzana, Ilaria, et al.
Publicado: (2016)

Co-Delivery of CPT-11 and Panobinostat with Anti-GD2 Antibody Conjugated Immunoliposomes for Targeted Combination Chemotherapy
por: Jose, Gils, et al.
Publicado: (2020)

4-Hydrazino-1-methylpyrazolo[3,4-d]pyrimidine
por: Dolzhenko, Anton V., et al.
Publicado: (2009)

Anti-GD2 Immunoliposomes for Targeted Delivery of the Survivin Inhibitor Sepantronium Bromide (YM155) to Neuroblastoma Tumor Cells
por: Gholizadeh, Shima, et al.
Publicado: (2018)

4-Benzylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2013)

Exploration of Pyrazolo[1,5‐a]pyrimidines as Membrane‐Bound Pyrophosphatase Inhibitors
por: Johansson, Niklas G., et al.
Publicado: (2021)

Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides
por: Tintori, Cristina, et al.
Publicado: (2018)

A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia
por: Laurenzana, Ilaria, et al.
Publicado: (2016)

Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine Derivatives
por: Abunada, Nada M., et al.
Publicado: (2008)

Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Anti-Survival Effect of SI306 and Its Derivatives on Human Glioblastoma Cells
por: Monteleone, Lorenzo, et al.
Publicado: (2022)

Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure–activity profile
por: Cacciari, Barbara, et al.
Publicado: (2006)

Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
por: Kandeel, Manal M., et al.
Publicado: (2012)

7-Chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidine
por: Bassoude, Ibtissam, et al.
Publicado: (2013)

NMR-Verified Dearomatization of 5,7-Substituted Pyrazolo[1,5-a]pyrimidines
por: Novikova, Daria, et al.
Publicado: (2023)

Correction to: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c] pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Targeting immunoliposomes to EGFR-positive glioblastoma
por: Kasenda, B., et al.
Publicado: (2022)

The Olive Leaves Extract Has Anti-Tumor Effects against Neuroblastoma through Inhibition of Cell Proliferation and Induction of Apoptosis
por: Morandi, Fabio, et al.
Publicado: (2021)

Retinoids Delivery Systems in Cancer: Liposomal Fenretinide for Neuroectodermal-Derived Tumors
por: Bensa, Veronica, et al.
Publicado: (2021)

Bone Marrow Environment in Metastatic Neuroblastoma
por: Brignole, Chiara, et al.
Publicado: (2021)

2-Anilino-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonitrile
por: Mohamed, Shaaban K., et al.
Publicado: (2012)

Crystal structure of 4-allylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2014)

Synthesis of Some Novel Pyrazolo[1,5-a]pyrimidine Derivatives and Their Application as Disperse Dyes
por: Al-Etaibi, Alya M., et al.
Publicado: (2011)

Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold
por: Baillache, Daniel J., et al.
Publicado: (2020)

Pyrazolo[1,5-a]pyrimidines-based fluorophores: a comprehensive theoretical-experimental study
por: Tigreros, Alexis, et al.
Publicado: (2020)

Pyrazolo-triazolo-pyrimidine Scaffold as a Molecular Passepartout for the Pan-Recognition of Human Adenosine Receptors
por: Salmaso, Veronica, et al.
Publicado: (2023)

Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
por: Nassar, Ibrahim F., et al.
Publicado: (2022)

Nanocarrier-Mediated Targeting of Tumor and Tumor Vascular Cells Improves Uptake and Penetration of Drugs into Neuroblastoma
por: Pastorino, Fabio, et al.
Publicado: (2013)

Palladium-Catalyzed Intramolecular Cross-Dehydrogenative Coupling: Synthesis of Fused Imidazo[1,2-a]pyrimidines and Pyrazolo[1,5-a]pyrimidines
por: Reddy Kotla, Siva K., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qja1lb4nk9dc9uhmumioln6i7v