Targeting an MDM2/MYC Axis to Overcome Drug Resistance in Multiple Myeloma

SIMPLE SUMMARY: We show that high expression of MDM2 is associated with poor prognosis and enhanced drug resistance in human myeloma cell lines (HMCLs). Inhibition of MDM2 by RNAi or by the MDM2/XIAP dual inhibitor MX69 significantly increased the sensitivity of resistant HMCLs and primary MM sample...

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Detalles Bibliográficos
Autores principales: Faruq, Omar, Zhao, Davidson, Shrestha, Mariusz, Vecchione, Andrea, Zacksenhaus, Eldad, Chang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945937/
https://www.ncbi.nlm.nih.gov/pubmed/35326742
http://dx.doi.org/10.3390/cancers14061592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945937/
https://www.ncbi.nlm.nih.gov/pubmed/35326742
http://dx.doi.org/10.3390/cancers14061592

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